We are seeing this issue pretty consistently across the board with IE9 and IE10, and everything we have researched has not worked. We notice that if we are logged in as administrator on a computer (both PC's running Windows 7 and zero-client terminals), we do not experience the issue. When we log back in as the user, we cannot open, save, or save as any downloads.
We have deleted all appropriate registry entries, removed and reinstalled IE9 and IE10 on different computers, removed any group policy that may apply to our internet settings for testing, and removed our av program for testing only.
Across the net we see multiple questions on this issue, but no clear-cut answer. Has anyone come up with a standard answer for this? Very frustrating...we didn't experience this on the same systems, same operating system, when we were on IE8.